WHAT IS STEM CELL TECHNOLOGY ?

WHAT IS STEM CELL TECHNOLOGY


Vet-Stem Regenerative Cell Therapy is based on a clinical technology originally licensed from Artecel Inc., Sunnyvale, CA. Original patents from University of Pittsburgh and Duke University.

• Rationale based on consistent therapeutic success in numerous animal models of disease (see sidebar)
• Adipose-derived adult stem cells (Vet-Stem Regenerative Cells: VSRC™)
• Autologous cell therapy
• Currently used in horses with bowed tendons, ligament injuries, and fractures, and in dogs with osteoarthritis
• More than 2,000 horses treated since 2003
• No systemic adverse events reported and <>3-6
• Demonstrated efficacy with VSRC therapy in horses and dogs
  • Cornell University double-blind, placebo controlled study⁵
  • Retrospective studies^3,4
  • Case studies⁶

Why use adipose-derived regenerative cells rather than regenerative cells derived from bone marrow?
Adipose-derived regenerative cells are:

• Readily available source
• Can be collected in far greater concentrations than those from bone marrow²⁴
• Able to differentiate into multiple lineages implicating their potential in bone, cartilage, and cardiac repair²³ (See figure above)
• Fractions isolated from adipose tissue contain a heterogeneous mixture of regenerative cells, including:²³
  • Mesenchymal stem cells
  • Endothelial progenitor cells
  • Pericytes
  • Immune cells
  • Fibroblasts
  • Other growth factor-secreting bioactive cells

Differences in Regenerative Medicine compared to traditional medicine;

• Does not rely on a single target receptor or a single pathway for its action
• Regenerative cell mixture is delivered either directly to the traumatic wound (e.g.: tendonitis, desmitis, fracture) or are delivered systemically (e.g.: liver disease, renal disease)
• Regenerative cells can differentiate into many tissue types, induce repair, and stimulate regeneration²²
• Regenerative cells "communicate" with the cells of their local environment through paracrine and autocrine modalities, creating the optimal environment for natural healing²⁵
• Regenerative cells produce a variety of both secreted and cell surface substances that regulate tissue growth, integrity, and function²⁵