Popular Posts

Sunday, May 30, 2010

WHAT IS STEM CELL TECHNOLOGY ?


WHAT IS STEM CELL TECHNOLOGY


Vet-Stem Regenerative Cell Therapy is based on a clinical technology originally licensed from Artecel Inc., Sunnyvale, CA. Original patents from University of Pittsburgh and Duke University.

  • Rationale based on consistent therapeutic success in numerous animal models of disease (see sidebar)
  • Adipose-derived adult stem cells (Vet-Stem Regenerative Cells: VSRC™)
  • Autologous cell therapy
  • Currently used in horses with bowed tendons, ligament injuries, and fractures, and in dogs with osteoarthritis
  • More than 2,000 horses treated since 2003
  • No systemic adverse events reported and <>3-6
  • Demonstrated efficacy with VSRC therapy in horses and dogs
    • Cornell University double-blind, placebo controlled study5
    • Retrospective studies3,4
    • Case studies6
Why use adipose-derived regenerative cells rather than regenerative cells derived from bone marrow?
Adipose-derived regenerative cells are:
  • Readily available source
  • Can be collected in far greater concentrations than those from bone marrow24
  • Able to differentiate into multiple lineages implicating their potential in bone, cartilage, and cardiac repair23 (See figure above)
  • Fractions isolated from adipose tissue contain a heterogeneous mixture of regenerative cells, including:23
    • Mesenchymal stem cells
    • Endothelial progenitor cells
    • Pericytes
    • Immune cells
    • Fibroblasts
    • Other growth factor-secreting bioactive cells
Differences in Regenerative Medicine compared to traditional medicine;
  • Does not rely on a single target receptor or a single pathway for its action
  • Regenerative cell mixture is delivered either directly to the traumatic wound (e.g.: tendonitis, desmitis, fracture) or are delivered systemically (e.g.: liver disease, renal disease)
  • Regenerative cells can differentiate into many tissue types, induce repair, and stimulate regeneration22
  • Regenerative cells "communicate" with the cells of their local environment through paracrine and autocrine modalities, creating the optimal environment for natural healing25
  • Regenerative cells produce a variety of both secreted and cell surface substances that regulate tissue growth, integrity, and function25

No comments:

Post a Comment

Related Posts Plugin for WordPress, Blogger...